Siklosporin

Siklosporin
Data klinikal
Sebutan	/ˌsaɪkləˈspɔːrɪn/
Nama dagang	Neoral, Sandimmune, lain-lain
Nama lain	siklosporin, siklosporin A, siklosporina A, siklosporin A (CsA), cyclosporine (USAN AS)
AHFS/Drugs.com	Monograph
MedlinePlus	a601207
Data lesen	EU EMA: by INN;
Kategori; kehamilan	AU: C; ;
Kaedah; pemberian	Mulut, IV, titisan mata
Kelas ubat	imunosupresan; perencat kalsineurin; perubatan mata
Kod ATC	L04AD01 (WHO) S01XA18;
Status perundangan
Status perundangan	AU: S4 (Preskripsi sahaja) ; UK: POM (Preskripsi sahaja) ; AS: Rx sahaja ;
Data farmakokinetik
Bioketersediaan	Pelbagai
Metabolisme	CYP3A4 hati
Penyingkiran separuh hayat	Pelbagai (kira-kira 24 jam)
Perkumuhan	Hempedu
Pengecam
	Nama IUPAC (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33- [(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl] -6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl- 1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;
Nombor CAS	59865-13-3 ;
PubChem CID	5284373;
IUPHAR/BPS	1024;
DrugBank	DB00091 ;
ChemSpider	4447449 ;
UNII	83HN0GTJ6D;
KEGG	D00184 ;
ChEMBL	ChEMBL160 ;
CompTox Dashboard (EPA)	DTXSID0020365 ;
ECHA InfoCard	100.119.569
Data kimia dan fizikal
Formula	C62H111N11O12
Jisim molar	1202.61 g/mol
Model 3D (JSmol)	Gambar interaktif;
	SMILES CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H] (C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C) C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C;
	InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 ; Key:PMATZTZNYRCHOR-CGLBZJNRSA-N ;
	(what is this?) (verify)

Siklosporin atau siklosporina merupakan ubat imunosuppresan dan produk asli.^[3] Ia diambil melalui mulut atau oleh suntikan dalam pembuluh darah untuk artritis reumatoid, psoriasis, penyakit Crohn, sindrom nefrotik, dan transplantasi organ untuk mencegah penolakan.^[4] Ia juga digunakan sebagai ubat penitis mata untuk keratokonjunktivitis sicca (mata kering).^[5]

Rujukan

^ "cyclosporin". Dictionary.com Unabridged. Random House. n.d. Diarkibkan daripada yang asal pada 2010-11-18. Dicapai pada 2011-07-13. Unknown parameter |deadurl= ignored (bantuan)
^ Laupacis A, Keown PA, Ulan RA, McKenzie N, Stiller CR (May 1982). "Cyclosporin A: a powerful immunosuppressant". Canadian Medical Association Journal. 126 (9): 1041–6. PMC 1863293. PMID 7074504.
^ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. m/s. 221. ISBN 9789241547659. Diarkibkan daripada yang asal (PDF) pada 13 December 2016. Dicapai pada 8 December 2016. Unknown parameter |dead-url= ignored (bantuan)
^ "Cyclosporine". The American Society of Health-System Pharmacists. Diarkibkan daripada yang asal pada 17 October 2016. Dicapai pada 8 December 2016. Unknown parameter |dead-url= ignored (bantuan)
^ "Cyclosporine eent". The American Society of Health-System Pharmacists. Diarkibkan daripada yang asal pada 13 January 2016. Dicapai pada 8 December 2016. Unknown parameter |dead-url= ignored (bantuan)

Pautan luar

[1] "cyclosporin". Dictionary.com Unabridged. Random House. n.d. Diarkibkan daripada yang asal pada 2010-11-18. Dicapai pada 2011-07-13. Unknown parameter |deadurl= ignored (bantuan)

[2] Laupacis A, Keown PA, Ulan RA, McKenzie N, Stiller CR (May 1982). "Cyclosporin A: a powerful immunosuppressant". Canadian Medical Association Journal. 126 (9): 1041–6. PMC 1863293. PMID 7074504.

[WHO2008-3] WHO Model Formulary 2008 (PDF). World Health Organization. 2009. m/s. 221. ISBN 9789241547659. Diarkibkan daripada yang asal (PDF) pada 13 December 2016. Dicapai pada 8 December 2016. Unknown parameter |dead-url= ignored (bantuan)

[AHFS2016-4] "Cyclosporine". The American Society of Health-System Pharmacists. Diarkibkan daripada yang asal pada 17 October 2016. Dicapai pada 8 December 2016. Unknown parameter |dead-url= ignored (bantuan)

[AHFS2016B-5] "Cyclosporine eent". The American Society of Health-System Pharmacists. Diarkibkan daripada yang asal pada 13 January 2016. Dicapai pada 8 December 2016. Unknown parameter |dead-url= ignored (bantuan)

[1]

[2]

[3]

[4]

[5]

Data klinikal


Sebutan	/ˌsaɪkləˈspɔːrɪn/^[1]
Nama dagang	Neoral, Sandimmune, lain-lain
Nama lain	siklosporin, siklosporin A,^[2] siklosporina A, siklosporin A (CsA), cyclosporine (USAN AS)
AHFS/Drugs.com	Monograph
MedlinePlus	a601207
Data lesen	EU EMA: by INN
Kategori kehamilan	AU: C
Kaedah pemberian	Mulut, IV, titisan mata
Kelas ubat	imunosupresan perencat kalsineurin perubatan mata
Kod ATC	L04AD01 (WHO) S01XA18
Status perundangan
Status perundangan	AU: S4 (Preskripsi sahaja) UK: POM (Preskripsi sahaja) AS: Rx sahaja
Data farmakokinetik
Bioketersediaan	Pelbagai
Metabolisme	CYP3A4 hati
Penyingkiran separuh hayat	Pelbagai (kira-kira 24 jam)
Perkumuhan	Hempedu
Pengecam
Nama IUPAC (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33- [(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl] -6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl- 1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Nombor CAS	59865-13-3^Y
PubChem CID	5284373
IUPHAR/BPS	1024
DrugBank	DB00091^N
ChemSpider	4447449^Y
UNII	83HN0GTJ6D
KEGG	D00184^Y
ChEMBL	ChEMBL160^Y
CompTox Dashboard (EPA)	DTXSID0020365
ECHA InfoCard	100.119.569
Data kimia dan fizikal
Formula	C₆₂H₁₁₁N₁₁O₁₂
Jisim molar	1202.61 g/mol
Model 3D (JSmol)	Gambar interaktif
SMILES CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H] (C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C) C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1^Y Key:PMATZTZNYRCHOR-CGLBZJNRSA-N^Y
^NY (what is this?) (verify)