| Estrogen | ER RBA (%) | Berat uterus (%) | Uterotrofi | Aras LH (%) | RBA SHBG (%) |
|---|---|---|---|---|---|
| Kawalan | – | 100 | – | 100 | – |
| Estradiol (E2) | 100 | 506 ± 20 | +++ | 12–19 | 100 |
| Estron (E1) | 11 ± 8 | 490 ± 22 | +++ | ? | 20 |
| Estriol (E3) | 10 ± 4 | 468 ± 30 | +++ | 8–18 | 3 |
| Estetrol (E4) | 0.5 ± 0.2 | ? | Tak aktif | ? | 1 |
| 17α-Estradiol | 4.2 ± 0.8 | ? | ? | ? | ? |
| 2-Hidroksiestradiol | 24 ± 7 | 285 ± 8 | +b | 31–61 | 28 |
| 2-Metoksiestradiol | 0.05 ± 0.04 | 101 | Tak aktif | ? | 130 |
| 4-Hidroksiestradiol | 45 ± 12 | ? | ? | ? | ? |
| 4-Metoksiestradiol | 1.3 ± 0.2 | 260 | ++ | ? | 9 |
| 4-Fluoroestradiola | 180 ± 43 | ? | +++ | ? | ? |
| 2-Hidroksiestron | 1.9 ± 0.8 | 130 ± 9 | Tak aktif | 110–142 | 8 |
| 2-Metoksiestron | 0.01 ± 0.00 | 103 ± 7 | Tak aktif | 95–100 | 120 |
| 4-Hidroksiestron | 11 ± 4 | 351 | ++ | 21–50 | 35 |
| 4-Metoksiestron | 0.13 ± 0.04 | 338 | ++ | 65–92 | 12 |
| 16α-Hidroksiestron | 2.8 ± 1.0 | 552 ± 42 | +++ | 7–24 | <0.5 |
| 2-Hidroksiestriol | 0.9 ± 0.3 | 302 | +b | ? | ? |
| 2-Metoksiestriol | 0.01 ± 0.00 | ? | Tak aktif | ? | 4 |
| Nota: Nilai ditunjukkan dalam bentuk purata ± sisihan piawai (SD) atau julat. ER RBA = Keberkaitan penambatan relatif terhadap reseptor-reseptor estrogen pada sitosol uterus tikus. Berat uterus = Peratusan perubahan pada berat basah uterus pada tikus yang diovariektomi selepas 72 jam dengan pemberian 1 μg/jam melalui pengimplanan subkutaneus pam-pam osmotik secara berterusan. Aras-aras LH = Aras-aras hormon peluteinan yang relatif kepada ukuran dasar tikus-tikur yang diovariektomi selepas pemberian ubatan secara berterusan selama 24 sehingga 72 jam melalui implan subkutaneus. Nota kaki: a = sebatian sintetik (yakni bukan endogenus). b = Kesan uterotrofik atipikal yang mendatar dalam masa 48 jam (uterotrofi estradiol berterusan secara linear sehingga 72 jam). Sumber-sumber: [1][2][3][4][5][6][7][8][9] | |||||
Pendokumenan templatLihat juga
Rujukan
- ^ Martucci C, Fishman J (March 1976). "Uterine estrogen receptor binding of catecholestrogens and of estetrol (1,3,5(10)-estratriene-3,15alpha,16alpha,17beta-tetrol)". Steroids. 27 (3): 325–333. doi:10.1016/0039-128x(76)90054-4. PMID 178074. S2CID 54412821.
- ^ Martucci C, Fishman J (December 1977). "Direction of estradiol metabolism as a control of its hormonal action--uterotrophic activity of estradiol metabolites". Endocrinology. 101 (6): 1709–1715. doi:10.1210/endo-101-6-1709. PMID 590186.
- ^ Fishman J, Martucci C (December 1978). "Differential biological activity of estradiol metabolites". Pediatrics. 62 (6 Pt 2): 1128–1133. doi:10.1542/peds.62.6.1128. PMID 724350. S2CID 29609115.
- ^ Martucci CP, Fishman J (December 1979). "Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion". Endocrinology. 105 (6): 1288–1292. doi:10.1210/endo-105-6-1288. PMID 499073.
- ^ Fishman J, Martucci CP (1980). "New Concepts of Estrogenic Activity: the Role of Metabolites in the Expression of Hormone Action". Dalam Pasetto N, Paoletti R, Ambrus JL (penyunting). The Menopause and Postmenopause. m/s. 43–52. doi:10.1007/978-94-011-7230-1_5. ISBN 978-94-011-7232-5.
- ^ Fishman J, Martucci C (September 1980). "Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology". The Journal of Clinical Endocrinology and Metabolism. 51 (3): 611–615. doi:10.1210/jcem-51-3-611. PMID 7190977.
- ^ Martucci CP (July 1983). "The role of 2-methoxyestrone in estrogen action". Journal of Steroid Biochemistry. 19 (1B): 635–638. doi:10.1016/0022-4731(83)90229-7. PMID 6310247.
- ^ Fishman J, Martucci C (1980). "Dissociation of biological activities in metabolites of estradiol". Dalam McLachlan JA (penyunting). Estrogens in the Environment: Proceedings of the Symposium on Estrogens in the Environment, Raleigh, North Carolina, U.S.A., September 10-12, 1979. Elsevier. m/s. 131–145. ISBN 9780444003720.
- ^ Kuhl H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 Suppl 1: 3–63. doi:10.1080/13697130500148875. PMID 16112947. S2CID 24616324.