Joseph Leonard Goldstein ForMemRS (lahir 18 April 1940) ialah ahli biokimia Amerika. Beliau menerima Hadiah Nobel dalam Fisiologi atau Perubatan pada tahun 1985, bersama dengan penyelidik Universiti Texas, Michael Stuart Brown, untuk kajian mereka mengenai kolesterol.[1] Mereka mendapati bahawa sel manusia mempunyai reseptor lipoprotein berkepekatan rendah (LDL) yang menghilangkan kolesterol dari darah dan apabila reseptor LDL tidak hadir dalam bilangan yang mencukupi, individu-individu akan mengalami hiperkolesterolemia dan menjadi berisiko untuk penyakit berkaitan kolesterol, terutamanya jantung koronari penyakit.[2] Kajian mereka membawa kepada perkembangan ubat statin.[3][4][5]
Kertas penyelidikan
[sunting | sunting sumber]- Brown MS, Goldstein JL (June 2012). "Reflections – Scientific side trips: six excursions from the beaten path". J. Biol. Chem. 287 (27): 22418–22435. doi:10.1074/jbc.X112.381681. PMC 3391146. PMID 22584575.
- Brown MS, Goldstein JL (May 2011). "Richard G.W. Anderson (1940–2011) and the birth of receptor-mediated endocytosis". J. Cell Biol. 193 (4): 601–603. doi:10.1083/jcb.201104136. PMC 3166872. PMID 21576388.
- Goldstein JL, Brown MS (April 2009). "History of Discovery: The LDL Receptor". Arterioscler. Thromb. Vasc. Biol. 29 (4): 431–438. doi:10.1161/ATVBAHA.108.179564. PMC 2740366. PMID 19299327.
- Brown MS, Goldstein JL (April 2009). "Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL". J. Lipid Res. 50 (Supplement): S15–S27. doi:10.1194/jlr.R800054-JLR200. PMC 2674699. PMID 18974038.
- Brown MS, Goldstein JL (October 2004). "A tribute to Akira Endo, discoverer of a "penicillin" for cholesterol". Atherosclerosis Supplements. 5 (3): 13–16. doi:10.1016/j.atherosclerosissup.2004.08.007.
- Brown MS, Goldstein JL (April 1986). "A receptor-mediated pathway for cholesterol homeostasis". Science. 232 (4746): 34–47. doi:10.1126/science.3513311. PMID 3513311.
- Brown MS, Goldstein JL (March 1974). "Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity". Proceedings of the National Academy of Sciences of the United States of America. 71 (3): 788–792. doi:10.1073/pnas.71.3.788. PMC 388099. PMID 4362634.
- Goldstein JL, Brown MS (October 1973). "Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol". Proceedings of the National Academy of Sciences of the United States of America. 70 (10): 2804–2808. doi:10.1073/pnas.70.10.2804. PMC 427113. PMID 4355366.
Rujukan
[sunting | sunting sumber]- ^ Badge, Peter (2007) "Joseph Goldstein". Nobel Faces. John Wiley & Sons. ISBN 9783527406784. p 300.
- ^ Encyclopedia of Global Health, Volume 1 by Luca Prono, edited by Yawei Zhang
- ^ Raju, T. N. (2000). "The Nobel Chronicles". The Lancet. 355 (9201): 416. doi:10.1016/S0140-6736(05)74047-2.
- ^ The Cholesterol Wars: The Skeptics Vs. the Preponderance of Evidence By Daniel Steinberg
- ^ "Highly Cited Researchers - The Most Influential Scientific Minds". highlycited.com. Dicapai pada 23 March 2018.
Pautan luar
[sunting | sunting sumber]- Biografi Hadiah Nobel .
- Journal of Clinical Investigation .
- Joseph Goldstein, Projek Pencahayaan Nobel, Muzium Orang Yahudi di Beit Hatfutsot
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