(R,R)-Tetrahidrokrisena - Wikipedia Bahasa Melayu, ensiklopedia bebas

(R,R)-Tetrahydrochrysene
Pengecam
	Nama IUPAC (5R,11R)-5,11-Diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol;
Nombor CAS	138090-06-9;
PubChem CID	446849;
ChemSpider	394097;
Data kimia dan fizikal
Formula	C22H24O2
Jisim molar	320.43 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CCC1CC2=C(C=CC(=C2)O)C3=C1C4=C(CC3CC)C=C(C=C4)O;
	InChI InChI=1S/C22H24O2/c1-3-13-9-15-11-17(23)6-8-20(15)22-14(4-2)10-16-12-18(24)5-7-19(16)21(13)22/h5-8,11-14,23-24H,3-4,9-10H2,1-2H3/t13-,14-/m1/s1; Key:MASYAWHPJCQLSW-ZIAGYGMSSA-N;

(R,R)-Tetrahidrokrisena ((R,R)-THC) ialah dadah yang digunakan untuk mengkaji reseptor estrogen dalam penyelidikan saintifik. Ia juga antagonis ERβ dan agonis ERα dengan daya tarikan 10 kali lebih tinggi untuk ERβ berbanding dengan ERα.^[1]^[2]

Rujukan

^ Ying Chen (2008). The Role of Steroids in the Regulation of Oocyte Cyst Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary. ProQuest. m/s. 101–. ISBN 978-0-549-74620-1.
^ Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL (2002). "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism". Nat. Struct. Biol. 9 (5): 359–64. doi:10.1038/nsb787. PMID 11953755.

[Chen2008-1] Ying Chen (2008). The Role of Steroids in the Regulation of Oocyte Cyst Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary. ProQuest. m/s. 101–. ISBN 978-0-549-74620-1.

[pmid11953755-2] Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL (2002). "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism". Nat. Struct. Biol. 9 (5): 359–64. doi:10.1038/nsb787. PMID 11953755.

[1]

[2]

Pengecam

Nama IUPAC (5R,11R)-5,11-Diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol
Nombor CAS	138090-06-9
PubChem CID	446849
ChemSpider	394097
Data kimia dan fizikal
Formula	C₂₂H₂₄O₂
Jisim molar	320.43 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES CCC1CC2=C(C=CC(=C2)O)C3=C1C4=C(CC3CC)C=C(C=C4)O
InChI InChI=1S/C22H24O2/c1-3-13-9-15-11-17(23)6-8-20(15)22-14(4-2)10-16-12-18(24)5-7-19(16)21(13)22/h5-8,11-14,23-24H,3-4,9-10H2,1-2H3/t13-,14-/m1/s1 Key:MASYAWHPJCQLSW-ZIAGYGMSSA-N